Bone Marrow–Derived Matrix Metalloproteinase-14
نویسندگان
چکیده
منابع مشابه
Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14
MMP-11 is a key factor in physiopathological tissue remodeling. As an active form is secreted, its activity must be tightly regulated to avoid detrimental effects. Although TIMP-1 and TIMP-2 reversibly inhibit MMP-11, another more drastic scenario, presumably via hydrolysis, could be hypothesized. In this context, we have investigated the possible implication of MMP-14, since it exhibits a spat...
متن کاملBone-marrow-derived matrix metalloproteinase-14: a novel target for plaque stability.
Derived Matrix Metalloproteinase-14 : A Novel Target for Plaque Stability − Bone Marrow Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.107.756346 2008;117:863-865 Circulation. http://circ.ahajournal...
متن کاملMatrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.
BACKGROUND Interstitial collagen plays a crucial structural role in arteries. Although in vitro results suggest collagenase activity for membrane-bound matrix metalloproteinase type 1 (MMP-14), in vivo evidence for such a function in atherosclerosis remains scant. METHODS AND RESULTS Because Mmp14-/- mice die by 3 weeks of age, this study used lethally irradiated low-density lipoprotein recep...
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Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is not fully understood. MMP14 is a potent pericellular collagenase that can cleave type I collagen in vitro. In this study, we show that tendon development is arrested in Scleraxis-Cre::Mmp14 lox/lox mice that are unable to release col...
متن کاملCompetitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Membrane type 1 matrix metalloproteinase (MT1-MMP) is a potent modulator of the pericellular environment and promotes tumor cell invasion and proliferation in many types of tumor. The activation of proMMP-2 and processing of collagen I by MT1-MMP have been thought to be important for its tumor-promoting function. These activities can be inhibited by mutant forms of MT1-MMP lacking the catalytic...
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ژورنال
عنوان ژورنال: Circulation
سال: 2008
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.107.756346